Journal article

Detectable HIV-1 in semen in individuals with very low blood viral loads


Research Areas

Publication Details

Author list: Kariuki SM, Selhorst P, Norman J, Cohen K, Rebe K, Williamson C, Dorfman JR

Publisher: BMC (part of Springer Nature)

Publication year: 2020

Journal: Virology Journal

Volume number: 17

Issue number: 1

Start page: 1

End page: 5

Total number of pages: 5

ISSN: 1743-422X

eISSN: 1743-422X

URL: https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01300-6


Abstract

Background
Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 reservoir in the male genital tract. However, the status of this reservoir in men living with HIV-1 who are not under treatment is underexplored and has implications for understanding the origins and evolution of the reservoir.

Finding
Forty-three HIV-1 positive, antiretroviral therapy naïve study participants attending a men’s health clinic were studied. Semen viral loads and blood viral loads were generally correlated, with semen viral loads generally detected in individuals with blood viral loads > 10,000 cp/ml. However, we found 1 individual with undetectable viral loads (<20cp/ml) and 2 individuals with very low blood viral load (97 and 333cp/ml), but with detectable HIV-1 in semen (485–1157 copies/semen sample). Blood viral loads in the first individual were undetectable when tested three times over the prior 5 years.

Conclusions
Semen HIV-1 viral loads are usually related to blood viral loads, as we confirm. Nonetheless, this was not true in a substantial minority of individuals suggesting unexpectedly high levels of replication in the male genital tract in a few individuals, despite otherwise effective immune control. This may reflect establishment of a local reservoir of HIV-1 populations.


Projects

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Keywords

HIV-1


Last updated on 2020-09-10 at 13:17