Journal article

Changing Incidence and Risk Factors for Kaposi Sarcoma by Time Since Starting Antiretroviral Therapy: Collaborative Analysis of 21 European Cohort Studies


Research Areas

Currently no objects available


Publication Details

Author list: Wyss N, Zwahlen M, Bohlius J, Clifford G, Campbell M, Chakraborty R, Bonnet F, Chene G, Bani-Sadr F, Verbon A, Zangerle R, Paparizos V, Prins M, Dronda F, Le Moing V, Quiros-Roldan E, Mussini C, Miro JM, Meyer L, Vehreschild JJ, Obel N, Mocroft A, Sabin C, Brockmeyer N, Boue F, Spagnuolo V, Hasse B, De Wit S, Roca B, Egger M

Publisher: Oxford University Press (OUP): Policy A1 - Oxford Open Option C

Publication year: 2016

Journal: Clinical Infectious Diseases

Journal name: CLINICAL INFECTIOUS DISEASES

Volume number: 63

Issue number: 10

Start page: 1373

End page: 1379

Total number of pages: 7

ISSN: 1058-4838

eISSN: 1537-6591


Abstract

Background. Kaposi sarcoma (KS) remains a frequent cancer in human immunodeficiency virus (HIV)-positive patients starting combination antiretroviral therapy (cART). We examined incidence rates and risk factors for developing KS in different periods after starting cART in patients from European observational HIV cohorts.Methods. We included HIV-positive adults starting cART after 1 January 1996. We analyzed incidence rates and risk factors for developing KS up to 90 and 180 days and 1, 2, 5, and 8 years after cART start and fitted univariable and ultivariable Cox regression models.Results. We included 109 461 patients from 21 prospective clinical cohorts in Europe with 916 incident KS cases. The incidence rate per 100 000 person-years was highest 6 months after starting cART, at 953 (95% confidence interval, 866-1048), declining to 82 (68-100) after 5-8 years. In multivariable analyses adjusted for exposure group, origin, age, type of first-line regimen, and calendar year, low current CD4 cell counts increased the risk of developing KS throughout all observation periods after cART initiation. Lack of viral control was not associated with the hazard of developing KS in the first year after cART initiation, but was over time since starting cART increasingly positively associated (P<.001 for interaction).Conclusion. In patients initiating cART, both incidence and risk factors for KS change with time since starting cART. Whereas soon after starting cART low CD4 cell count is the dominant risk factor, detectable HIV-1 RNA viral load becomes an increasingly important risk factor in patients who started cART several years earlier, independently of immunodeficiency.


Projects

Currently no objects available


Keywords

Antiretroviral therapy, HIV, Kaposi sarcoma, Risk factors


Last updated on 2017-21-04 at 17:25