Journal article

Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia


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Publication Details

Author list: Tanser F, Vinikoor M, Macete E, Wood R, Stinson K, Garone D, Fatti G, Phiri S, Giddy J, Chimbetete C, Malisita K, Eley B, Fritz C, Hobbins M, Kamenova K, Fox M, Prozesky H, Technau K, Sawry S, Zangerle R, Touloumi G, Warszawski J, Meyer L, Dabis F, Krause MM, Ghosn J, Leport C, Wittkop L, Reiss P, Wit F, Prins M, Bucher H, Sabin C, Gibb D, Fatkenheuer G, Del Amo J, Obel N, Thorne C, Mocroft A, Kirk O, Stephan C, Perez-Hoyos S, Hamouda O, Bartmeyer B, Chkhartishvili N, Noguera-Julian A, Antinori A, Monforte AD, Brockmeyer N, Prieto L, Rojo P, Soriano-Arandes A, Battegay M, Kouyos R, Mussini C, Tookey P, Casabona J, Miro JM, Castagna A, Konopnick D, Goetghebuer T, Sonnerborg A, Torti C, Teira R, Garrido M, Haerry D, De Wit S,del Amo J, Raben D, Chene G, Judd A, Barger D, Schwimmer C, Termote M, Campbell M, Frederiksen C, Friis-Moller N, Berenguer J, Bohlius J, Bouteloup V, Cozzi-Lepri A, Davies MA, Dorrucci M, Dunn D, Egger M, Furrer H, Guiguet M, Grabar S,Kirk O, Lambotte O, Leroy V, Lodi S, Matheron S, Monge S, Nakagawa F, Paredes R, Peters L, Phillips A, Puoti M, Schomaker M, Smit C, Sterne J, Thiebaut R, van der Valk M, Ly PS, Khol V, Sarun SM, Ung VB, Tucker J, Kumarasamy N, Saghayam S, Chandrasekaran E, Wati DK, Atmikasari LPP, Malino IY, Kurniati N, Muktiarti D, Fong SM, Lim M, Daut F, Yusoff NKN, Mohamad P, Razali KA, Mohamed TJ, Mohammed NADR, Nallusamy R, Chan KC, Sudjaritruk T, Sirisanthana V, Aurpibul L, Oberdorfer P, Hansudewechakul R, Denjanta S, Srisuk W, Kongphonoi A, Lumbiganon P, Kosalaraksa P, Tharnprisan P, Udomphanit T, Jourdain G, Bunupuradah T, Puthanakit T, Prasitsuebsai W, Chanthaweethip W, Chokephaibulkit K, Lapphra K, Phongsamart W, Sricharoenchai S, Truong KH, Du QT, Nguyen CH, Do VC, Ha TM, An VT, Nguyen LV, Khu DTK, Pham AN, Nguyen LT, Le ON, Sohn AH, Sethaputra C, Cooper DA, Law MG, Kariminia A

Publisher: Oxford University Press (OUP): Policy A1 - Oxford Open Option C

Publication year: 2016

Journal: Clinical Infectious Diseases

Journal name: CLINICAL INFECTIOUS DISEASES

Volume number: 63

Issue number: 9

Start page: 1245

End page: 1253

Total number of pages: 9

ISSN: 1058-4838

eISSN: 1537-6591


Abstract

Background. The burden of Kaposi sarcoma (KS) in human immunodeficiency virus (HIV)-infected children and adolescents on combination antiretroviral therapy (cART) has not been compared globally.Methods. We analyzed cohort data from the International Epidemiologic Databases to Evaluate AIDS and the Collaboration of Observational HIV Epidemiological Research in Europe. We included HIV-infected children aged <16 years at cART initiation from 1996 onward. We used Cox models to calculate hazard ratios (HRs), adjusted for region and origin, sex, cART start year, age, and HIV/AIDS stage at cART initiation.Results. We included 24 991 children from eastern Africa, southern Africa, Europe and Asia; 26 developed KS after starting cART. Incidence rates per 100 000 person-years (PYs) were 86 in eastern Africa (95% confidence interval [CI], 55-133), 11 in southern Africa (95% CI, 4-35), and 81 (95% CI, 26-252) in children of sub-Saharan African (SSA) origin in Europe. The KS incidence rates were 0/100 000 PYs in children of non-SSA origin in Europe (95% CI, 0-50) and in Asia (95% CI, 0-27). KS risk was lower in girls than in boys (adjusted HR [aHR], 0.3; 95% CI, .1-. 9) and increased with age (10-15 vs 0-4 years; aHR, 3.4; 95% CI, 1.2-10.1) and advanced HIV/AIDS stage (CDC stage C vs A/B; aHR, 2.4; 95% CI,.8-7.3) at cART initiation.Conclusions. HIV-infected children from SSA but not those from other regions, have a high risk of developing KS after cART initiation. Early cART initiation in these children might reduce KS risk.


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Keywords

Antiretroviral therapy, Children, HIV, Kaposi sarcoma


Last updated on 2017-07-08 at 12:38