Journal article

Excessive volume of hydrogel injectates may compromise the efficacy for the treatment of acute myocardial infarction


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Publication Details

Author list: Wise P., Davies NH., Sirry MS., Kortsmit J., Dubuis L., Chai C., Baaijens FPT., Franz T

Publisher: Wiley: 12 months

Publication year: 2016

Journal: International Journal for Numerical Methods in Biomedical Engineering

Journal name: International Journal for Numerical Methods in Biomedical Engineering

Volume number: 32

Issue number: 12

Start page: 2772

End page: 2785

Total number of pages: 14

ISSN: 2040-7939

eISSN: 2040-7947

URL: https://api.elsevier.com/content/abstract/scopus_id/84962815670


Abstract

Biomaterial injectates are promising as a therapy for myocardial infarction to inhibit the adverse ventricular remodeling. The current study explored interrelated effects of injectate volume and infarct size on treatment efficacy. A finite element model of a rat heart was utilized to represent ischemic infarcts of 10%, 20%, and 38% of left ventricular wall volume and polyethylene glycol hydrogel injectates of 25%, 50%, and 75% of the infarct volume. Ejection fraction was 49.7% in the healthy left ventricle and 44.9%, 46.4%, 47.4%, and 47.3% in the untreated 10% infarct and treated with 25%, 50%, and 75% injectate, respectively. Maximum end-systolic infarct fiber stress was 41.6, 53.4, 44.7, 44.0, and 45.3 kPa in the healthy heart, the untreated 10% infarct, and when treated with the three injectate volumes, respectively. Treating the 10% and 38% infarcts with the 25% injectate volume reduced the maximum end-systolic fiber stress by 16.3% and 34.7% and the associated strain by 30.2% and 9.8%, respectively. The results indicate the existence of a threshold for injectate volume above which efficacy does not further increase but may decrease. The efficacy of an injectate in reducing infarct stress and strain changes with infarct size. Copyright © 2016 John Wiley & Sons, Ltd.


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Keywords

Biomaterial, finite element method


Last updated on 2017-04-12 at 10:00