Journal article review

HIV-1 latency is maintained by the estrogen receptor

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Publication Details

Author list: Bick A, Hapgood J.P.

Publisher: Elsevier: 12 months / Elsevier (Cell Press)

Publication year: 2018

Journal: Trends in Microbiology

Volume number: 26

Issue number: 11

Start page: 891

End page: 892

Total number of pages: 2

ISSN: 0966-842X

eISSN: 1878-4380



Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combination with other latency-reversing agents.


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Last updated on 2019-18-04 at 10:07