Journal article

HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth


Research Areas

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Publication Details

Author list: Sheward D., Marais J., Bekker V., Murrell B., Eren K., Bhiman J., Nonyane M., Garrett N., Woodman Z., Abdool Karim Q., Abdool Karim S., Morris L., Moore P., Williamson C.

Publisher: Elsevier (Cell Press): 12 month embargo

Publication year: 2018

Journal: Cell Host and Microbe

Journal name: Cell Host and Microbe

Volume number: 24

Issue number: 4

Start page: 593

End page: 599

Total number of pages: 7

ISSN: 1931-3128

eISSN: 1934-6069

URL: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054711453∨igin=inward


Abstract

Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine development. HIV superinfection (re-infection with a second strain following an established infection) has been associated with neutralization breadth, and can provide insights into how the immune system responds to sequential exposure to distinct HIV envelope glycoproteins (Env). Characterizing the neutralizing antibody (nAb) responses in four superinfected women revealed that superinfection does not boost memory nAb responses primed by the first infection or promote nAb responses to epitopes conserved in both infecting viruses. While one superinfected individual developed potent bnAbs, superinfection was likely not the driver as the nAb response did not target an epitope conserved in both viruses. Rather, sequential exposure led to nAbs specific to each Env but did not promote bnAb development. Thus, sequential immunization with heterologous Envs may not be sufficient to focus the immune response onto conserved epitopes.


Projects

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Keywords

HIV, Vaccines


Last updated on 2019-19-08 at 15:25